Environment Influences Tumor Progression and Transcriptional Subtype in a New Model of Pancreatic Cancer.

ABSTRACT

In this issue, Miyabayashi and colleagues describe a novel intraductal model of pancreatic cancer that allows modeling of the transcriptional subtypes of pancreatic cancer. Using this model, they are able to observe subtype switching driven by the microenvironment, a process at least partially mediated by RAS signaling.See related article by Miyabayashi et al., p. 1566.