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Passive Transfer of Vaccine-Elicited Antibodies Protects against SIV in Rhesus Macaques.
Alter, Galit; Yu, Wen-Han; Chandrashekar, Abishek; Borducchi, Erica N; Ghneim, Khader; Sharma, Ashish; Nedellec, Rebecca; McKenney, Katherine R; Linde, Caitlyn; Broge, Thomas; Suscovich, Todd J; Linnekin, Tom; Abbink, Peter; Mercado, Noe B; Nkolola, Joseph P; McMahan, Katherine; Bondzie, Esther A; Hamza, Venous; Peter, Lauren; Kordana, Nicole; Mahrokhian, Shant; Seaman, Michael S; Li, Wenjun; Lewis, Mark G; Lauffenburger, Douglas A; Hangartner, Lars; Sekaly, Rafick-Pierre; Barouch, Dan H.
Afiliação
  • Alter G; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
  • Yu WH; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
  • Chandrashekar A; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Borducchi EN; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Ghneim K; Case Western Reserve University, Cleveland, OH 44106, USA.
  • Sharma A; Case Western Reserve University, Cleveland, OH 44106, USA.
  • Nedellec R; The Scripps Research Institute, La Jolla, CA 92037, USA.
  • McKenney KR; The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Linde C; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
  • Broge T; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
  • Suscovich TJ; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
  • Linnekin T; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
  • Abbink P; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Mercado NB; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Nkolola JP; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • McMahan K; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Bondzie EA; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Hamza V; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Peter L; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Kordana N; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Mahrokhian S; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Seaman MS; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Li W; University of Massachusetts Medical School, Worcester, MA 01605, USA.
  • Lewis MG; Bioqual, Rockville, MD 20852, USA.
  • Lauffenburger DA; Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Hangartner L; The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Sekaly RP; Case Western Reserve University, Cleveland, OH 44106, USA.
  • Barouch DH; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address: dbarouch@bidmc.harvard.edu.
Cell ; 183(1): 185-196.e14, 2020 10 01.
Article em En | MEDLINE | ID: mdl-33007262
ABSTRACT
Several HIV-1 and SIV vaccine candidates have shown partial protection against viral challenges in rhesus macaques. However, the protective efficacy of vaccine-elicited polyclonal antibodies has not previously been demonstrated in adoptive transfer studies in nonhuman primates. In this study, we show that passive transfer of purified antibodies from vaccinated macaques can protect naive animals against SIVmac251 challenges. We vaccinated 30 rhesus macaques with Ad26-SIV Env/Gag/Pol and SIV Env gp140 protein vaccines and assessed the induction of antibody responses and a putative protective signature. This signature included multiple antibody functions and correlated with upregulation of interferon pathways in vaccinated animals. Adoptive transfer of purified immunoglobulin G (IgG) from the vaccinated animals with the most robust protective signatures provided partial protection against SIVmac251 challenges in naive recipient rhesus macaques. These data demonstrate the protective efficacy of purified vaccine-elicited antiviral antibodies in this model, even in the absence of virus neutralization.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Imunização Passiva / Vírus da Imunodeficiência Símia / Vacinas contra a SAIDS Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Imunização Passiva / Vírus da Imunodeficiência Símia / Vacinas contra a SAIDS Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article