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Acid-promoted synthesis and photophysical properties of substituted acridine derivatives.
Bian, Zi-Long; Lv, Xin-Xin; Li, Ya-Lan; Sun, Wen-Wu; Liu, Ji-Kai; Wu, Bin.
Afiliação
  • Bian ZL; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China. 2016027@mail.scuec.edu.cn jkliu@mail.kib.ac.cn 2015084@mail.scuec.edu.cn.
  • Lv XX; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China. 2016027@mail.scuec.edu.cn jkliu@mail.kib.ac.cn 2015084@mail.scuec.edu.cn.
  • Li YL; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China. 2016027@mail.scuec.edu.cn jkliu@mail.kib.ac.cn 2015084@mail.scuec.edu.cn.
  • Sun WW; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China. 2016027@mail.scuec.edu.cn jkliu@mail.kib.ac.cn 2015084@mail.scuec.edu.cn.
  • Liu JK; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China. 2016027@mail.scuec.edu.cn jkliu@mail.kib.ac.cn 2015084@mail.scuec.edu.cn.
  • Wu B; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China. 2016027@mail.scuec.edu.cn jkliu@mail.kib.ac.cn 2015084@mail.scuec.edu.cn.
Org Biomol Chem ; 18(40): 8141-8146, 2020 10 21.
Article em En | MEDLINE | ID: mdl-33016295
A simple and efficient synthetic protocol for the preparation of acridinium esters and amides through the cyclization and esterification or amidation of isatins with alcohols or amines as nucleophiles in the presence of CF3SO3H is established. A series of polycyclic acridine derivatives bearing large π-conjugated systems were obtained in high yields, including some key intermediates for the synthesis of biologically active molecules. The photophysical properties of these synthesized acridines were investigated, demonstrating that the sulfur heterocyclic acridine 9w was obtained in a high quantum yield.

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article