Paecilosetin Derivatives as Potent Antimicrobial Agents from Isaria farinosa.
J Nat Prod
; 83(10): 2915-2922, 2020 10 23.
Article
em En
| MEDLINE
| ID: mdl-33021377
ABSTRACT
Fifty-seven entomopathogenic microorganisms were screened against human pathogens and subjected to mass spectrometry molecular networking based dereplication. Isaria farinosa BSNB-1250, shown to produce potentially novel biologically active metabolites, was grown on a large scale on potato dextrose agar, and paecilosetin (1) and five new analogues (2-6) were subsequently isolated. The structures of the new compounds were elucidated using 1D and 2D NMR. The absolute configurations of compounds 1-6 were determined using Mosher ester derivatives (1, 3, 4), comparison of experimental and calculated ECD spectra (2-4 and 6), and single-crystal X-ray diffraction analysis (5). Compounds 1 and 5 exhibited strong antibacterial activity against MSSA and MRSA with MIC values of 1-2 µg/mL.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pirrolidinonas
/
Cordyceps
/
Anti-Infecciosos
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article