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Effectiveness of the Dexamethasone Implant in Lieu of Oral Corticosteroids in Intermediate and Posterior Uveitis Requiring Immunosuppression.
Berkenstock, Meghan K; Mir, Tahreem A; Khan, Irfan R; Burkholder, Bryn M; Chaon, Benjamin C; Shifera, Amde Selassie; Thorne, Jennifer E.
Afiliação
  • Berkenstock MK; The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Mir TA; The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Khan IR; The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Burkholder BM; The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Chaon BC; The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Shifera AS; The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Thorne JE; The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Ocul Immunol Inflamm ; 30(3): 741-749, 2022 Apr 03.
Article em En | MEDLINE | ID: mdl-33021854
PURPOSE: To evaluate dexamethasone intravitreal implant effectiveness in lieu of high-dose oral prednisone for short-term treatment of noninfectious intermediate and posterior uveitis in patients requiring immunosuppression. METHODS: This is a proof-of-concept, open-label, non-comparative clinical trial with 12-month follow-up. The primary outcome was uveitis control without additional prednisone at 6 and 12 months. Secondary outcomes were need for multiple implants or additional prednisone, and safety data. RESULTS: 20 patients (28 eyes) were enrolled- 16 eyes had control by 6 months; 20 by 12 months. No patients required high-dose prednisone. 6 patients enrolled on prednisone: 2 stopped; 4 tapered to 7.5 mg daily or less by 12 months. 16 eyes required multiple implants; five required cataract surgery; 12 required drops to control IOP; 2 underwent glaucoma surgery. CONCLUSIONS: The dexamethasone implant was effective in lieu of high-dose prednisone although the majority required multiple implants. All patients decreased or discontinued prednisone during follow-up.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Uveíte / Uveíte Posterior Tipo de estudo: Clinical_trials / Diagnostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Uveíte / Uveíte Posterior Tipo de estudo: Clinical_trials / Diagnostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article