MicroRNA124 and microRNA21-5p regulate migration, proliferation and differentiation of rat bone marrow mesenchymal stem cells.
Biosci Rep
; 40(10)2020 10 30.
Article
em En
| MEDLINE
| ID: mdl-33026076
ABSTRACT
Mesenchymal stem cells (MSCs) are multipotent stromal cells that can be a useful source of cells for the treatment of many diseases, including neurologic diseases. The curative effect of MSCs relies mostly on cell's capacity of migration, proliferation and differentiation. MicroRNAs (miRNAs) are small non-coding RNAs that play important roles on regulating various cell behaviors. Here, we report that miRNA-124 (miR124) and miRNA-21-5p (miR21-5p) display different regulatory roles on migration, proliferation and neuron differentiation of MSCs. MiR124 was shown greatly promoting MSCs migration and neuronal differentiation. MiR21-5p could significantly enhance the proliferation and neuronal differentiation ability of MSCs. MiR124 and miR21-5p synergistically promote differentiation of MSCs into neurons. Collectively, miR124 and miR21-5p can functionally regulate cell migration, proliferation and neuronal differentiation of MSCs. Therefore, miR124 and miR21-5p may be promising tools to improve transplantation efficiency for neural injury.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Movimento Celular
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MicroRNAs
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Proliferação de Células
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Neurogênese
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Células-Tronco Neurais
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Células-Tronco Mesenquimais
Limite:
Animals
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article