Ocular Surface Squamous Neoplasia: Clinicopathological Analysis and Treatment Outcome of 65 Cases.

ABSTRACT

OBJECTIVES: To find out the demography, clinical behaviour and outcome of ocular surface squamous neoplasia (OSSN) in North-west Pakistan. STUDY DESIGN: Case series. PLACE AND DURATION OF STUDY Department of Ophthalmology, Khyber Teaching Hospital, Peshawar, Pakistan, from March 2011 to December 2017. METHODOLOGY: All patients with OSSN consulting this department were registered. A special proforma was designed to document demography, clinical features, management, and follow-up of all cases. At the end of study, the data was analysed using SPSS version 25 and the result compiled. RESULTS: Sixty-five eyes with OSSN were included in the study, in which 40 (61.5%) were males and 25 (38.5%) were females. Mean age of the patients was 61.68 +12.76 years. Twenty-six (40%) patients were farmers and exposed to ultraviolet light for prolong period. Fifty-nine (90.8%) presented with a painless, reddish mass on ocular surface. Average size of neoplasm at presentation was 18.60 + 11.30 mm in large dimension. Histopathologically, 23 (35.4%) were carcinoma in situ and 41(63%) invasive squamous cell carcinoma. During the period of follow-up 41 (63.1%) cured, 21 (32.2%) developed recurrence, and 3 (4.6%) patients passed away. CONCLUSION: OSSN is common in North-west Pakistan. The presentation is late due to certain socio-economic factors; but overall behaviour of the neoplasm is almost the same as mentioned in other studies from different parts of the world. Key Words Ocular surface squamous neoplasia (OSSN), conjunctival squamous cell carcinoma, Carcinoma in situ.