Effects of carboxymethyl chitosan oligosaccharide on regulating immunologic function and inhibiting tumor growth.
Carbohydr Polym
; 250: 116994, 2020 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-33049904
ABSTRACT
Herein, the effects of carboxymethyl chitosan oligosaccharide (CM-COS) on regulating immunologic function and inhibiting hepatocellular tumor growth were evaluated. Results showed that CM-COS caused dramatic viability loss of hepatocellular carcinoma BEL-7402 with non-toxicity towards normal liver L-02 cells. CM-COS repressed tumor growth of hepatoma-22, and elevated the spleen index and thymus index of tumor-bearing mice. Contents of VEGF and MMP-9 were significantly down-regulated by CM-COS. Histological analyses revealed that CM-COS promoted tumor cell necrosis and produced no significant toxicity to spleen tissues. Moreover, expressions of Caspase-3 in tumor tissues and IL-2 in spleen tissues were signiï¬cantly activated by CM-COS. Additionally, in vitro cell viability, phagocytic capability and NO production of mouse peritoneal macrophages exposed to CM-COS were significantly higher. CM-COS remarkably increased the in vivo phagocytosing capacity of peritoneal macrophages of Kunming mice. Taken together, our ï¬ndings suggested that CM-COS might be potentially effective and non-toxic candidate as anti-hepatoma agents.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Oligossacarídeos
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Macrófagos Peritoneais
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Carcinoma Hepatocelular
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Quitosana
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Fígado
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Neoplasias Hepáticas
Limite:
Animals
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article