A functional context for heterogeneity of the circadian clock in cells.
PLoS Biol
; 18(10): e3000927, 2020 10.
Article
em En
| MEDLINE
| ID: mdl-33052900
ABSTRACT
Characterization of circadian systems at the organism level-a top-down approach-has led to definition of unifying properties, a hallmark of the science of chronobiology. The next challenge is to use a bottom-up approach to show how the molecular workings of the cellular circadian clock work as building blocks of those properties. We review new studies, including a recently published PLOS Biology paper by Nikhil and colleagues, that show how programmed but also stochastic generation of variation in cellular circadian period explain important adaptive features of entrained circadian phase.
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1
Base de dados:
MEDLINE
Assunto principal:
Relógios Circadianos
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article