Anti-LGI1 Encephalitis Developing Immunoglobulin Responsive Orthostatic Hypotension after Remission.
Intern Med
; 60(18): 3021-3024, 2021 Sep 15.
Article
em En
| MEDLINE
| ID: mdl-33055478
ABSTRACT
Anti-leucine-rich glioma-inactivated 1 (LGI1) antibody is associated with limbic encephalitis. We herein report a patient with anti-LGI1 encephalitis who developed severe orthostatic hypotension (OH) responsive to immunoglobulin therapy five years after developing symptoms of encephalitis. A 71-year-old man presented with amnesia caused by limbic encephalitis. The symptoms of encephalitis improved partially without any immunotherapy. Five years later, he developed severe OH, and anti-LGI1 antibody was positive. The catecholamine dynamics indicated that the central autonomic nervous system was the lesion of his OH. Intravenous immunoglobulin therapy improved the OH. This case suggests that anti-LGI1 antibody can be associated with severe OH.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Encefalite Límbica
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Canais de Potássio de Abertura Dependente da Tensão da Membrana
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Encefalite
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Glioma
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Hipotensão Ortostática
Tipo de estudo:
Etiology_studies
Limite:
Aged
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Humans
/
Male
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article