Differential response of rat splenic lymphocytes to short-term and long-term neuroendocrine challenges: possible desensitization of the cellular immune response to corticosteroids.
J Neuroimmunol
; 16(2): 253-9, 1987 Oct.
Article
em En
| MEDLINE
| ID: mdl-3305570
ABSTRACT
The effects of acute or chronic in vivo or in vitro exposures to supra-physiologic doses of isoproterenol, insulin or dexamethasone on rat splenic lymphocyte proliferation were investigated. Acutely, all in vivo challenges inhibited mitogen-induced lymphocyte proliferation, and correlated to increased corticosterone levels. However, chronic in vivo exposure to dexamethasone resulted in lymphocyte activity which was equivalent to controls, while chronic isoproterenol treatment enhanced the lymphocyte response to mitogen. These data suggest that chronic stress may result in a desensitization of the immune system to corticosteroids as well as a direct in vivo modulation by isoproterenol to enhance lymphocyte proliferation.
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Base de dados:
MEDLINE
Assunto principal:
Dexametasona
/
Ativação Linfocitária
/
Linfócitos
/
Adrenalectomia
/
Imunidade Celular
/
Insulina
/
Isoproterenol
Limite:
Animals
Idioma:
En
Ano de publicação:
1987
Tipo de documento:
Article