Proanthocyanidins-Mediated Nrf2 Activation Ameliorates Glucocorticoid-Induced Oxidative Stress and Mitochondrial Dysfunction in Osteoblasts.

Chen, Liang; Hu, Sun-Li; Xie, Jun; Yan, De-Yi; Weng, She-Ji; Tang, Jia-Hao; Wang, Bing-Zhang; Xie, Zhong-Jie; Wu, Zong-Yi; Yang, Lei

Chen, Liang; Hu, Sun-Li; Xie, Jun; Yan, De-Yi; Weng, She-Ji; Tang, Jia-Hao; Wang, Bing-Zhang; Xie, Zhong-Jie; Wu, Zong-Yi; Yang, Lei.

Afiliação

Chen L; Department of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Childrens Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Hu SL; Key Laboratory of Orthopaedics of Zhejiang Province, Wenzhou 325000, China.
Xie J; Department of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Childrens Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Yan DY; Key Laboratory of Orthopaedics of Zhejiang Province, Wenzhou 325000, China.
Weng SJ; Department of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Childrens Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Tang JH; Key Laboratory of Orthopaedics of Zhejiang Province, Wenzhou 325000, China.
Wang BZ; Department of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Childrens Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Xie ZJ; Key Laboratory of Orthopaedics of Zhejiang Province, Wenzhou 325000, China.
Wu ZY; Department of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Childrens Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Yang L; Department of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Childrens Hospital of Wenzhou Medical University, Wenzhou 325000, China.

Oxid Med Cell Longev ; 2020: 9102012, 2020.

Article em En | MEDLINE | ID: mdl-33062149

Assuntos

Glucocorticoides/farmacologia; Mitocôndrias/efeitos dos fármacos; Fator 2 Relacionado a NF-E2/metabolismo; Estresse Oxidativo/efeitos dos fármacos; Proantocianidinas/farmacologia; Animais; Caspase 3/genética; Caspase 3/metabolismo; Diferenciação Celular/efeitos dos fármacos; Células Cultivadas; Dexametasona/farmacologia; Mitocôndrias/metabolismo; Osteoblastos/citologia; Osteoblastos/metabolismo; Osteogênese/efeitos dos fármacos; Ratos; Ratos Sprague-Dawley; Transdução de Sinais/efeitos dos fármacos; Superóxido Dismutase/genética; Superóxido Dismutase/metabolismo; Proteína X Associada a bcl-2/genética; Proteína X Associada a bcl-2/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Estresse Oxidativo / Proantocianidinas / Fator 2 Relacionado a NF-E2 / Glucocorticoides / Mitocôndrias Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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