Rebamipide with Proton Pump Inhibitors (PPIs) versus PPIs Alone for the Treatment of Endoscopic Submucosal Dissection-Induced Ulcers: A Meta-analysis.
Biomed Res Int
; 2020: 7196782, 2020.
Article
em En
| MEDLINE
| ID: mdl-33062694
ABSTRACT
OBJECTIVE:
To contrast the effect of rebamipide with proton pump inhibitors (PPIs) versus PPIs alone for the treatment of endoscopic submucosal dissection (ESD-) induced ulcers.METHODS:
PubMed, Embase, the Cochrane library, the WanFang database, and China National Knowledge Infrastructure (CNKI) were searched to identify studies that met the inclusion criteria.RESULTS:
Nine randomized controlled trials (RCTs) were recognized, including 1170 patients. In general, rebamipide plus PPIs acted better than PPIs alone against ESD-induced ulcers at four weeks (RR = 1.42, 95% CI 1.13-1.78, P = 0.003) but showed no significant differences at eight weeks (RR = 1.03, 95% CI 0.97-1.10, P = 0.315). The use of rebamipide plus PPIs was superior to PPIs alone for ESD-induced ulcers greater than 20 mm in size (20-40 mm RR = 1.98, 95% CI 1.22-3.23, P = 0.006; >40 mm RR = 5.14, 95% CI 1.49-17.74, P = 0.010). In addition, rebamipide plus PPI therapy was discovered to be significantly more effective than PPIs alone for lower ESD-induced ulcers (RR = 1.82, 95% CI 1.04-3.20, P = 0.037). There were no significant differences between the treatment groups with the ulcer reduction rate.CONCLUSION:
Evidences now available show rebamipide plus PPIs is practical for protecting against ESD-induced ulcers at four weeks but not at eight weeks, especially large ulcers (>20 mm). However, we still need more high-quality RCTs in the future to supplement our conclusions.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Úlcera Gástrica
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Quinolonas
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Alanina
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Inibidores da Bomba de Prótons
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Ressecção Endoscópica de Mucosa
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Antiulcerosos
Tipo de estudo:
Clinical_trials
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Etiology_studies
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Prognostic_studies
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Systematic_reviews
Limite:
Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article