Lateral Gene Transfer of Anion-Conducting Channelrhodopsins between Green Algae and Giant Viruses.
Curr Biol
; 30(24): 4910-4920.e5, 2020 12 21.
Article
em En
| MEDLINE
| ID: mdl-33065010
ABSTRACT
Channelrhodopsins (ChRs) are light-gated ion channels widely used as optogenetic tools for manipulating neuronal activity. The currently characterized ChR families include green algal and cryptophyte cation-conducting ChRs (CCRs) and cryptophyte, haptophyte, and stramenopile anion-conducting ChRs (ACRs). Here, we report the discovery of a new family of phylogenetically distinct ChRs encoded by marine giant viruses and acquired from their unicellular green algal hosts. These previously unknown viral and green algal ChRs act as ACRs when expressed in cultured neuroblastoma-derived cells and are likely involved in behavioral responses to light.
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Base de dados:
MEDLINE
Assunto principal:
Transferência Genética Horizontal
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Clorófitas
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Vírus Gigantes
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Channelrhodopsins
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Genes Virais
Limite:
Animals
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article