Studies towards the total synthesis of drimentine C. Preparation of the AB and CDEF ring fragments.
European J Org Chem
; 2020(16): 2448-2453, 2020 May 03.
Article
em En
| MEDLINE
| ID: mdl-33071626
ABSTRACT
The drimentine family is a class of hybrid isoprenoids derived from actinomycete bacteria. Members of this family display weak antitumor and antibacterial activity. Herein we report our efforts toward the total synthesis of drimentine C using three distinct approaches incorporating palladium-catalyzed cyanoamidation, reductive cross-coupling, and photoredox-catalyzed α-alkylation of an aldehyde as key steps. Our synthetic efforts use a convergent synthesis to assemble the terpenoid and alkaloid portions of drimentine C from readily available l-tryptophan, l-proline, and (+)-sclareolide.
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MEDLINE
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En
Ano de publicação:
2020
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Article