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Bronchoscopically delivered microwave ablation in an in vivo porcine lung model.
Sebek, Jan; Kramer, Steve; Rocha, Rob; Yu, Kun-Chang; Bortel, Radoslav; Beard, Warren L; Biller, David S; Hodgson, David S; Ganta, Charan K; Wibowo, Henky; Yee, John; Myers, Renelle; Lam, Stephen; Prakash, Punit.
Afiliação
  • Sebek J; Dept of Electrical and Computer Engineering, Kansas State University Manhattan, Manhattan, KS, USA.
  • Kramer S; Dept of Circuit Theory, Czech Technical University in Prague, Prague, Czech Republic.
  • Rocha R; Broncus Medical, Inc., San Jose, CA, USA.
  • Yu KC; Broncus Medical, Inc., San Jose, CA, USA.
  • Bortel R; Broncus Medical, Inc., San Jose, CA, USA.
  • Beard WL; Dept of Circuit Theory, Czech Technical University in Prague, Prague, Czech Republic.
  • Biller DS; Dept of Clinical Sciences, Kansas State University, Manhattan, KS, USA.
  • Hodgson DS; Dept of Clinical Sciences, Kansas State University, Manhattan, KS, USA.
  • Ganta CK; Dept of Clinical Sciences, Kansas State University, Manhattan, KS, USA.
  • Wibowo H; Dept of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS, USA.
  • Yee J; Phenomapper, LLC., San Jose, CA, USA.
  • Myers R; Dept of Thoracic Surgery, Vancouver General Hospital and the University of British Columbia, Vancouver, Canada.
  • Lam S; Dept of Thoracic Surgery, Vancouver General Hospital and the University of British Columbia, Vancouver, Canada.
  • Prakash P; Dept of Integrative Oncology, BC Cancer Research Center and the University of British Columbia, Vancouver, Canada.
ERJ Open Res ; 6(4)2020 Oct.
Article em En | MEDLINE | ID: mdl-33083442
BACKGROUND: Percutaneous microwave ablation is clinically used for inoperable lung tumour treatment. Delivery of microwave ablation applicators to tumour sites within lung parenchyma under virtual bronchoscopy guidance may enable ablation with reduced risk of pneumothorax, providing a minimally invasive treatment of early-stage tumours, which are increasingly detected with computed tomography (CT) screening. The objective of this study was to integrate a custom microwave ablation platform, incorporating a flexible applicator, with a clinically established virtual bronchoscopy guidance system, and to assess technical feasibility for safely creating localised thermal ablations in porcine lungs in vivo. METHODS: Pre-ablation CTs of normal pigs were acquired to create a virtual model of the lungs, including airways and significant blood vessels. Virtual bronchoscopy-guided microwave ablation procedures were performed with 24-32 W power (at the applicator distal tip) delivered for 5-10 mins. A total of eight ablations were performed in three pigs. Post-treatment CT images were acquired to assess the extent of damage and ablation zones were further evaluated with viability stains and histopathologic analysis. RESULTS: The flexible microwave applicators were delivered to ablation sites within lung parenchyma 5-24 mm from the airway wall via a tunnel created under virtual bronchoscopy guidance. No pneumothorax or significant airway bleeding was observed. The ablation short axis observed on gross pathology ranged 16.5-23.5 mm and 14-26 mm on CT imaging. CONCLUSION: We have demonstrated the technical feasibility for safely delivering microwave ablation in the lung parenchyma under virtual bronchoscopic guidance in an in vivo porcine lung model.

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Guideline Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Guideline Idioma: En Ano de publicação: 2020 Tipo de documento: Article