Pharmacokinetics and Pharmacodynamics of JNJ-55920839, an Antibody Targeting Interferon &#945;/&#969;, in Healthy Subjects and Subjects with Mild-to-Moderate Systemic Lupus Erythematosus.

Yao, Zhenling; Loggia, Laura; Fink, Damien; Chevrier, Marc; Marciniak, Stanley; Sharma, Amarnath; Xu, Zhenhua

Pharmacokinetics and Pharmacodynamics of JNJ-55920839, an Antibody Targeting Interferon α/ω, in Healthy Subjects and Subjects with Mild-to-Moderate Systemic Lupus Erythematosus.

Yao, Zhenling; Loggia, Laura; Fink, Damien; Chevrier, Marc; Marciniak, Stanley; Sharma, Amarnath; Xu, Zhenhua.

Afiliação

Yao Z; Janssen Research and Development, LLC, Clin Pharm TA PA, SH32-10590, Welsh & McKean Road, Spring House, PA, 19477, USA.
Loggia L; Janssen Research and Development, LLC, Clin Pharm TA PA, SH32-10590, Welsh & McKean Road, Spring House, PA, 19477, USA.
Fink D; Janssen Research and Development, LLC, Clin Pharm TA PA, SH32-10590, Welsh & McKean Road, Spring House, PA, 19477, USA.
Chevrier M; Janssen Research and Development, LLC, Clin Pharm TA PA, SH32-10590, Welsh & McKean Road, Spring House, PA, 19477, USA.
Marciniak S; Janssen Research and Development, LLC, Clin Pharm TA PA, SH32-10590, Welsh & McKean Road, Spring House, PA, 19477, USA.
Sharma A; Janssen Research and Development, LLC, Clin Pharm TA PA, SH32-10590, Welsh & McKean Road, Spring House, PA, 19477, USA.
Xu Z; Janssen Research and Development, LLC, Clin Pharm TA PA, SH32-10590, Welsh & McKean Road, Spring House, PA, 19477, USA. ZXu5@its.jnj.com.

Clin Drug Investig ; 40(12): 1127-1136, 2020 Dec.

Article em En | MEDLINE | ID: mdl-33085033

Assuntos

Anticorpos Monoclonais Humanizados; Interferon-alfa/antagonistas & inibidores; Lúpus Eritematoso Sistêmico/tratamento farmacológico; Administração Intravenosa; Adulto; Anticorpos Monoclonais Humanizados/farmacocinética; Anticorpos Monoclonais Humanizados/farmacologia; Anticorpos Monoclonais Humanizados/uso terapêutico; Área Sob a Curva; Disponibilidade Biológica; Método Duplo-Cego; Feminino; Voluntários Saudáveis; Humanos; Infusões Intravenosas; Injeções Subcutâneas; Masculino; Pessoa de Meia-Idade; Placebos

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Interferon-alfa / Anticorpos Monoclonais Humanizados / Lúpus Eritematoso Sistêmico Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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