Fatal autonomic failure due to premanifesting Parkinson's disease only diagnosed at autopsy.

Bodi, Istvan; Hagen, Ellen Merete; Ingle, Gordon Thorpe; Lunn, Michael P

Bodi, Istvan; Hagen, Ellen Merete; Ingle, Gordon Thorpe; Lunn, Michael P.

Afiliação

Bodi I; Clinical Neuropathology King's College Hospital NHS Foundation Trust London UK.
Hagen EM; Autonomic Unit National Hospital for Neurology and Neurosurgery London UK.
Ingle GT; Neurology Department Whipps Cross University Hospital London UK.
Lunn MP; Centre for Neuromuscular Disease National Hospital for Neurology and Neurosurgery London UK.

Clin Case Rep ; 8(10): 1997-1999, 2020 Oct.

Article em En | MEDLINE | ID: mdl-33088537

ABSTRACT

ABSTRACT

A 46-year-old male had 11-year history of cryptic autonomic dysfunction. He developed a fatal autonomic failure with diffuse hypoxic brain injury. Histology examination of medulla oblongata and the celiac ganglion revealed many α-synuclein immunoreactive Lewy bodies confirming the diagnosis of premanifesting Parkinson's disease (PD). PNS involvement in PD is underappreciated.

Palavras-chave

Lewy body disease; Parkinson's disease; autonomic dysfunction; multiple system atrophy; neurodegeneration; αsynuclein

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Article