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Impaired inhibitory processing: a new therapeutic target for autism and psychosis?
Heinze, Kareen; Barron, Helen C; Howes, Emma K; Ramaswami, Mani; Broome, Matthew R.
Afiliação
  • Heinze K; School of Psychology, University of Birmingham; and Institute for Mental Health, University of Birmingham; and Centre for Human Brain Health, University of Birmingham, Edgbaston, UK.
  • Barron HC; Medical Research Council Brain Network Dynamics Unit, Department of Pharmacology, University of Oxford; and Wellcome Centre for Integrative Neuroimaging, University of Oxford, UK.
  • Howes EK; School of Psychology, University of Birmingham, Edgbaston, UK.
  • Ramaswami M; Trinity College Institute of Neuroscience, Trinity College Dublin, University of Dublin, Ireland.
  • Broome MR; School of Psychology, University of Birmingham; and Institute for Mental Health, University of Birmingham; and Centre for Human Brain Health, University of Birmingham, Edgbaston, UK.
Br J Psychiatry ; 218(6): 295-298, 2021 06.
Article em En | MEDLINE | ID: mdl-33092656
In the healthy brain, homeostatic balance between excitation and inhibition maintains neural stability. Reduced inhibition may explain shared symptoms observed in autism and psychosis. Here we review evidence suggesting that altered levels of gamma-aminobutyric acid (GABA) may underlie both disorders, providing a potential cross-diagnostic therapeutic target.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtornos Psicóticos / Transtorno Autístico / Transtorno do Espectro Autista Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtornos Psicóticos / Transtorno Autístico / Transtorno do Espectro Autista Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article