Phosphorylation of SMURF2 by ATM exerts a negative feedback control of DNA damage response.

Tang, Liu-Ya; Thomas, Adam; Zhou, Ming; Zhang, Ying E

Tang, Liu-Ya; Thomas, Adam; Zhou, Ming; Zhang, Ying E.

Afiliação

Tang LY; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Thomas A; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Zhou M; Protein Characterization Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, Maryland, USA.
Zhang YE; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. Electronic address: zhangyin@mail.nih.gov.

J Biol Chem ; 295(52): 18485-18493, 2020 12 25.

Article em En | MEDLINE | ID: mdl-33097595

Assuntos

Proteínas Mutadas de Ataxia Telangiectasia/metabolismo; Cromatina/metabolismo; Dano ao DNA; Reparo do DNA; Retroalimentação Fisiológica; Ubiquitina-Proteína Ligases/metabolismo; Animais; Proteínas Mutadas de Ataxia Telangiectasia/genética; Cromatina/genética; Instabilidade Genômica; Humanos; Camundongos; Fosforilação; Ubiquitina-Proteína Ligases/genética; Ubiquitinação

Palavras-chave

ATM; DNA damage response; DNA repair; H2B ubiquitination; RNF20; SMURF2; histone modification; phosphorylation; ubiquitylation (ubiquitination)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dano ao DNA / Cromatina / Retroalimentação Fisiológica / Ubiquitina-Proteína Ligases / Reparo do DNA / Proteínas Mutadas de Ataxia Telangiectasia Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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