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Targeted CRISPR screening identifies PRMT5 as synthetic lethality combinatorial target with gemcitabine in pancreatic cancer cells.
Wei, Xiaolong; Yang, Jiekun; Adair, Sara J; Ozturk, Harun; Kuscu, Cem; Lee, Kyung Yong; Kane, William J; O'Hara, Patrick E; Liu, Denis; Demirlenk, Yusuf Mert; Habieb, Alaa Hamdi; Yilmaz, Ebru; Dutta, Anindya; Bauer, Todd W; Adli, Mazhar.
Afiliação
  • Wei X; Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22903.
  • Yang J; Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22903.
  • Adair SJ; Department of Surgery, University of Virginia School of Medicine, Charlottesville, VA 22903.
  • Ozturk H; Feinberg School of Medicine, Robert Lurie Comprehensive Cancer Center, Department of Obstetrics and Gynecology, The Northwestern University, Chicago, IL 60611.
  • Kuscu C; Transplant Research Institute, University of Tennessee Health Science Center, Memphis, TN 38163.
  • Lee KY; Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22903.
  • Kane WJ; Department of Surgery, University of Virginia School of Medicine, Charlottesville, VA 22903.
  • O'Hara PE; Department of Surgery, University of Virginia School of Medicine, Charlottesville, VA 22903.
  • Liu D; Department of Surgery, University of Virginia School of Medicine, Charlottesville, VA 22903.
  • Demirlenk YM; Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22903.
  • Habieb AH; Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22903.
  • Yilmaz E; Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22903.
  • Dutta A; Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22903.
  • Bauer TW; Department of Surgery, University of Virginia School of Medicine, Charlottesville, VA 22903.
  • Adli M; Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22903; adli@northwestern.edu.
Proc Natl Acad Sci U S A ; 117(45): 28068-28079, 2020 11 10.
Article em En | MEDLINE | ID: mdl-33097661
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Proteína-Arginina N-Metiltransferases / Desoxicitidina / Antineoplásicos Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Proteína-Arginina N-Metiltransferases / Desoxicitidina / Antineoplásicos Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article