[Ferroptosis in respiratory diseases].
Sheng Li Xue Bao
; 72(5): 575-585, 2020 Oct 25.
Article
em Zh
| MEDLINE
| ID: mdl-33106828
ABSTRACT
Ferroptosis is a novel form of regulated cell death which is dependent on iron and reactive oxygen species (ROS) and associated with the accumulation of lipid peroxides. It is obviously different from other cell death types in terms of morphology, biochemistry, genetics, etc. Also, it is related to the production of iron catalyzed lipid peroxides which is triggered by non-enzymatic or enzymatic reactions. Ferroptosis has been proved to be involved in hematological diseases, cardio-cerebrovascular diseases, liver and kidney diseases. This paper will review the definition, mechanism, inducers of ferroptosis, as well as the function of ferroptosis in respiratory system. We expect to present a new concept for respiratory research and suggest potential targets for clinical prevention and treatment of respiratory diseases.
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Base de dados:
MEDLINE
Assunto principal:
Transtornos Respiratórios
/
Ferroptose
Limite:
Humans
Idioma:
Zh
Ano de publicação:
2020
Tipo de documento:
Article