Unresectable Chondrosarcomas Treated With Carbon Ion Radiotherapy: Relationship Between Dose-averaged Linear Energy Transfer and Local Recurrence.
Anticancer Res
; 40(11): 6429-6435, 2020 Nov.
Article
em En
| MEDLINE
| ID: mdl-33109581
ABSTRACT
BACKGROUND/AIM:
The local control rate of chondrosarcomas treated with carbon-ion radiotherapy (CIRT) worsens as tumour size increases, possibly because of the intra-tumoural linear energy transfer (LET) distribution. This study aimed to evaluate the relationship between local recurrence and intra-tumoural LET distribution in chondrosarcomas treated with CIRT. PATIENTS ANDMETHODS:
Thirty patients treated with CIRT for grade 2 chondrosarcoma were included. Dose-averaged LET (LETd) distribution was calculated by the treatment planning system, and the relationship between LETd distribution in the planning tumour volume (PTV) and local control was evaluated.RESULTS:
The mean LETd value in PTV was similar between cases with and without recurrence. Recurrence was not observed in cases where the effective minimum LETd value exceeded 40 keV/µm.CONCLUSION:
LETd distribution in PTV is associated with local control in chondrosarcomas and patients treated with ion beams of higher LETd may have an improved local control rate for unresectable chondrosarcomas.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Doses de Radiação
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Condrossarcoma
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Radioterapia com Íons Pesados
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Recidiva Local de Neoplasia
Tipo de estudo:
Health_economic_evaluation
Limite:
Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article