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Racial disparities in survival outcomes among breast cancer patients by molecular subtypes.
Zhao, Fangyuan; Copley, Brenda; Niu, Qun; Liu, Fang; Johnson, Julie A; Sutton, Thomas; Khramtsova, Galina; Sveen, Elisabeth; Yoshimatsu, Toshio F; Zheng, Yonglan; Ibraheem, Abiola; Jaskowiak, Nora; Nanda, Rita; Fleming, Gini F; Olopade, Olufunmilayo I; Huo, Dezheng.
Afiliação
  • Zhao F; Department of Public Health Sciences, University of Chicago, Chicago, IL, USA.
  • Copley B; Comprehensive Cancer Center, University of Chicago, Chicago, IL, USA.
  • Niu Q; Section of Hematology and Oncology, Department of Medicine, University of Chicago, Chicago, IL, USA.
  • Liu F; Section of Hematology and Oncology, Department of Medicine, University of Chicago, Chicago, IL, USA.
  • Johnson JA; Center for Research Informatics, University of Chicago, Chicago, IL, USA.
  • Sutton T; Center for Research Informatics, University of Chicago, Chicago, IL, USA.
  • Khramtsova G; Section of Hematology and Oncology, Department of Medicine, University of Chicago, Chicago, IL, USA.
  • Sveen E; Section of Hematology and Oncology, Department of Medicine, University of Chicago, Chicago, IL, USA.
  • Yoshimatsu TF; Section of Hematology and Oncology, Department of Medicine, University of Chicago, Chicago, IL, USA.
  • Zheng Y; Section of Hematology and Oncology, Department of Medicine, University of Chicago, Chicago, IL, USA.
  • Ibraheem A; Section of Hematology and Oncology, Department of Medicine, University of Chicago, Chicago, IL, USA.
  • Jaskowiak N; Department of Surgery, University of Chicago, Chicago, IL, USA.
  • Nanda R; Section of Hematology and Oncology, Department of Medicine, University of Chicago, Chicago, IL, USA.
  • Fleming GF; Section of Hematology and Oncology, Department of Medicine, University of Chicago, Chicago, IL, USA.
  • Olopade OI; Section of Hematology and Oncology, Department of Medicine, University of Chicago, Chicago, IL, USA.
  • Huo D; Department of Public Health Sciences, University of Chicago, Chicago, IL, USA. dhuo@uchicago.edu.
Breast Cancer Res Treat ; 185(3): 841-849, 2021 Feb.
Article em En | MEDLINE | ID: mdl-33111220
PURPOSE: Differences in tumor biology, genomic architecture, and health care delivery patterns contribute to the breast cancer mortality gap between White and Black patients in the US. Although this gap has been well documented in previous literature, it remains uncertain how large the actual effect size of race is for different survival outcomes and the four breast cancer subtypes. METHODS: We established a breast cancer patient cohort at the University of Chicago Comprehensive Cancer Center. We chose five major survival outcomes to study: overall survival, recurrence-free survival, breast-cancer-specific survival, time-to-recurrence and post-recurrence survival. Cox proportional hazards models were used to estimate the hazard ratios between Black and White patients, adjusting for selected patient, tumor, and treatment characteristics, and also stratified by the four breast cancer subtypes. RESULTS: The study included 2795 stage I-III breast cancer patients (54% White and 38% Black). After adjusting for selected patient, tumor and treatment characteristics, Black patients still did worse than White patients in all five survival outcomes. The racial difference was highest within the HR-/HER2+ subgroup, in both overall survival (hazard ratio = 4.00, 95% CI 1.47-10.86) and recurrence-free survival (hazard ratio = 3.00, 95% CI 1.36-6.60), adjusting for age at diagnosis, cancer stage, and comorbidities. There was also a significant racial disparity within the HR+/HER2- group in both overall survival and recurrence-free survival. CONCLUSIONS: Our study confirmed that racial disparity existed between White and Black breast cancer patients in terms of both survival and recurrence, and found that this disparity was largest among HR-/HER2+ and HR+/HER2- patients.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama Tipo de estudo: Prognostic_studies Limite: Female / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama Tipo de estudo: Prognostic_studies Limite: Female / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article