Randomised clinical trial: combined impact and resistance training in adults with stable Crohn's disease.
Aliment Pharmacol Ther
; 52(6): 964-975, 2020 09.
Article
em En
| MEDLINE
| ID: mdl-33119156
ABSTRACT
BACKGROUND:
Crohn's disease (CD) is a predisposing factor for bone loss and muscle dysfunction, which could lead to osteoporotic fractures and physical disability, respectively.AIM:
To assess the effect of 6 months of combined impact and resistance training on bone mineral density (BMD) and muscle function in adults with CD.METHODS:
In this randomised controlled trial, 47 adults with stable CD were assigned to exercise (n = 23) or control (n = 24) groups and followed up for 6 months. The exercise group received usual care plus a 6-month combined impact and resistance training programme, involving three, 60-minute sessions per week and a gradual tapering of supervision to self-management. The control group received usual care alone. The primary outcomes were BMD (via dual energy X-ray absorptiometry) and muscle function (measures of upper and lower limb strength and endurance) at 6 months.RESULTS:
At 6 months, BMD values were superior in the exercise group with statistical significance at lumbar spine (adjusted mean difference 0.036 g/cm2, 95% CI 0.024-0.048; P < 0.001), but not at femoral neck (0.018 g/cm2, 0.001-0.035; P = 0.059) or greater trochanter (0.013 g/cm2, -0.019 to 0.045; P = 0.415) after correcting for multiple outcomes. The exercise group also had superior values for all muscle function outcomes (P < 0.001; unadjusted mean differences ranging 22.6â48.2%), and lower fatigue severity (P = 0.005). Three exercise-related adverse events were recorded two instances of light-headedness and one of nausea.CONCLUSIONS:
The intervention improved BMD and muscle function in adults with CD and appears as a suitable model of exercise for reducing future risk of osteoporotic fractures and disability. TRIAL REGISTRATION ISRCTN11470370.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doença de Crohn
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Densidade Óssea
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Treinamento Resistido
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Fraturas por Osteoporose
Tipo de estudo:
Clinical_trials
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Prognostic_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article