Recent Developments in Transition-Metal Catalyzed Direct C-H Alkenylation, Alkylation, and Alkynylation of Azoles.
Molecules
; 25(21)2020 Oct 27.
Article
em En
| MEDLINE
| ID: mdl-33121108
ABSTRACT
The transition metal-catalyzed C-H bond functionalization of azoles has emerged as one of the most important strategies to decorate these biologically important scaffolds. Despite significant progress in the C-H functionalization of various heteroarenes, the regioselective alkylation and alkenylation of azoles are still arduous transformations in many cases. This review covers recent advances in the direct C-H alkenylation, alkylation and alkynylation of azoles utilizing transition metal-catalysis. Moreover, the limitations of different strategies, chemoselectivity and regioselectivity issues will be discussed in this review.
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Base de dados:
MEDLINE
Assunto principal:
Azóis
/
Elementos de Transição
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Alcenos
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Alcinos
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article