P21 activated kinase-1 (PAK1) in macrophages is required for promotion of Th17 cell response during helminth infection.

Chang, Hao; He, Kai-Yue; Li, Chen; Ni, Yang-Yue; Li, Mai-Ning; Chen, Lin; Hou, Min; Zhou, Zikai; Xu, Zhi-Peng; Ji, Min-Jun

Chang, Hao; He, Kai-Yue; Li, Chen; Ni, Yang-Yue; Li, Mai-Ning; Chen, Lin; Hou, Min; Zhou, Zikai; Xu, Zhi-Peng; Ji, Min-Jun.

Afiliação

Chang H; Center for Global Health, Nanjing Medical University, Nanjing, China.
He KY; Department of Pathogen Biology, Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University, Nanjing, China.
Li C; Department of Pathogen Biology, Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University, Nanjing, China.
Ni YY; Department of Pathogen Biology, Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University, Nanjing, China.
Li MN; Department of Pathogen Biology, Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University, Nanjing, China.
Chen L; Department of Pathogen Biology, Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University, Nanjing, China.
Hou M; Department of Pathogen Biology, Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University, Nanjing, China.
Zhou Z; Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xu ZP; Department of Pathogen Biology, Jiangsu Province Key Laboratory of Modern Pathogen Biology, Nanjing Medical University, Nanjing, China.
Ji MJ; Center for Global Health, Nanjing Medical University, Nanjing, China.

J Cell Mol Med ; 24(24): 14325-14338, 2020 12.

Article em En | MEDLINE | ID: mdl-33124146

Assuntos

Helmintíase/metabolismo; Helmintíase/parasitologia; Macrófagos/imunologia; Macrófagos/metabolismo; Células Th17/imunologia; Células Th17/metabolismo; Quinases Ativadas por p21/metabolismo; Animais; Antígenos de Helmintos/imunologia; Biomarcadores; Citocinas/metabolismo; Modelos Animais de Doenças; Imunofenotipagem; Camundongos; Esquistossomose Japônica/imunologia; Esquistossomose Japônica/metabolismo; Esquistossomose Japônica/parasitologia; Subpopulações de Linfócitos T/imunologia; Subpopulações de Linfócitos T/metabolismo

Palavras-chave

IL-6; P21 Activated Kinase-1; Th17 cell; Treg cell; macrophage

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinases Ativadas por p21 / Células Th17 / Helmintíase / Macrófagos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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