Association of HERV-K and LINE-1 hypomethylation with reduced disease-free survival in melanoma patients.
Epigenomics
; 12(19): 1689-1706, 2020 10.
Article
em En
| MEDLINE
| ID: mdl-33125285
ABSTRACT
Aim:
To evaluate CpG methylation of long interspersed nuclear elements 1 (LINE-1) and human endogenous retrovirus K (HERV-K) retroelements as potential prognostic biomarkers in cutaneous melanoma. Materials &methods:
Methylation of HERV-K and LINE-1 retroelements was assessed in resected melanoma tissues from 82 patients ranging in age from 14 to 88 years. In addition, nevi from eight patients were included for comparison with nonmalignant melanocytic lesions.Results:
Methylation levels were lower in melanomas than in nevi. HERV-K and LINE-1 methylation were decreased in melanoma patients with clinical parameters associated with adverse prognosis, while they were independent of age and gender. Hypomethylation of HERV-K (but not LINE-1) was an independent predictor of reduced disease-free survival.Conclusion:
HERV-K hypomethylation can be a potential independent biomarker of melanoma recurrence.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
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Retroelementos
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Metilação de DNA
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Elementos Nucleotídeos Longos e Dispersos
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Melanoma
Tipo de estudo:
Prognostic_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article