Transcriptomic Analysis of Human Astrocytes In Vitro Reveals Hypoxia-Induced Mitochondrial Dysfunction, Modulation of Metabolism, and Dysregulation of the Immune Response.

Allen, Scott P; Seehra, Rajpinder Singh; Heath, Paul R; Hall, Benjamin P C; Bates, Jessica; Garwood, Claire J; Matuszyk, Martyna M; Wharton, Stephen B; Simpson, Julie E

Allen, Scott P; Seehra, Rajpinder Singh; Heath, Paul R; Hall, Benjamin P C; Bates, Jessica; Garwood, Claire J; Matuszyk, Martyna M; Wharton, Stephen B; Simpson, Julie E.

Afiliação

Allen SP; Sheffield Institute for Translational Neuroscience, 385a Glossop Road, University of Sheffield, Sheffield S10 2HQ, UK.
Seehra RS; Sheffield Institute for Translational Neuroscience, 385a Glossop Road, University of Sheffield, Sheffield S10 2HQ, UK.
Heath PR; Sheffield Institute for Translational Neuroscience, 385a Glossop Road, University of Sheffield, Sheffield S10 2HQ, UK.
Hall BPC; Sheffield Institute for Translational Neuroscience, 385a Glossop Road, University of Sheffield, Sheffield S10 2HQ, UK.
Bates J; Sheffield Institute for Translational Neuroscience, 385a Glossop Road, University of Sheffield, Sheffield S10 2HQ, UK.
Garwood CJ; Sheffield Institute for Translational Neuroscience, 385a Glossop Road, University of Sheffield, Sheffield S10 2HQ, UK.
Matuszyk MM; Sheffield Institute for Translational Neuroscience, 385a Glossop Road, University of Sheffield, Sheffield S10 2HQ, UK.
Wharton SB; Sheffield Institute for Translational Neuroscience, 385a Glossop Road, University of Sheffield, Sheffield S10 2HQ, UK.
Simpson JE; Sheffield Institute for Translational Neuroscience, 385a Glossop Road, University of Sheffield, Sheffield S10 2HQ, UK.

Int J Mol Sci ; 21(21)2020 Oct 28.

Article em En | MEDLINE | ID: mdl-33126586

Assuntos

Astrócitos/patologia; Hipóxia/fisiopatologia; Imunidade/genética; Mitocôndrias/patologia; Transcriptoma; Astrócitos/imunologia; Astrócitos/metabolismo; Células Cultivadas; Glicólise; Homeostase; Humanos; Técnicas In Vitro; Mitocôndrias/imunologia; Mitocôndrias/metabolismo

Palavras-chave

astrocyte; hypoxia; immune response; metabolism; mitochondrial dysfunction; transcriptome

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Astrócitos / Transcriptoma / Imunidade / Hipóxia / Mitocôndrias Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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