Early Life Antibiotic Prescriptions and Weight Outcomes in Children 10 Years of Age.
Acad Pediatr
; 21(2): 297-303, 2021 03.
Article
em En
| MEDLINE
| ID: mdl-33130067
ABSTRACT
OBJECTIVE:
We previously found that antibiotic use at <24 months of age was associated with slightly higher body weight at 5 years of age. In this study, we examine associations of early life antibiotic prescriptions with weight outcomes at 108 to 132 months of age ("10 years").METHODS:
We used electronic health record data from 2009 through 2016 from 10 health systems in PCORnet, a national distributed clinical research network. We examined associations of any (vs no) antibiotics at <24 months of age with body mass index z-score (BMI-z) at 10 years adjusted for confounders selected a priori. We further examined dose response (number of antibiotic episodes) and antibiotic spectrum (narrow and broad).RESULTS:
Among 56,727 included children, 57% received any antibiotics at <24 months; at 10 years, mean (standard deviation) BMI-z was 0.54 (1.14), and 36% had overweight or obesity. Any versus no antibiotic use at <24 months was associated with a slightly higher BMI-z at 10 years among children without a complex chronic condition (ß 0.03; 95% confidence interval [CI] 0.01, 0.05) or with a complex chronic condition (ß 0.09; 95% CI 0.03, 0.15). Any versus no antibiotic use was not associated with odds of overweight or obesity at 10 years among children without (odds ratio 1.02; 95% CI 0.97, 1.07) or with a complex chronic condition (odds ratio 1.07; 95% CI 0.96, 1.19).CONCLUSIONS:
The small and likely clinically insignificant associations in this study are consistent with our previous 5-year follow-up results, suggesting that, if this relationship is indeed causal, early increases in weight are small but maintained over time.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Sobrepeso
/
Antibacterianos
Limite:
Child
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Child, preschool
/
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article