A new role for matrix metalloproteinase-3 in the NGF metabolic pathway: Proteolysis of mature NGF and sex-specific differences in the continuum of Alzheimer's pathology.

Pentz, Rowan; Iulita, M Florencia; Mikutra-Cencora, Maya; Ducatenzeiler, Adriana; Bennett, David A; Cuello, A Claudio

Pentz, Rowan; Iulita, M Florencia; Mikutra-Cencora, Maya; Ducatenzeiler, Adriana; Bennett, David A; Cuello, A Claudio.

Afiliação

Pentz R; Department of Neurology and Neurosurgery, McGill University, Montreal, Canada. Electronic address: rowan.pentz@mail.mcgill.ca.
Iulita MF; Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada; Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain. Electronic address: florencia.iulita@gma
Mikutra-Cencora M; Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada. Electronic address: maya.mikutra-cencora@umontreal.ca.
Ducatenzeiler A; Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada. Electronic address: Adriana.ducatenzeiler@mcgill.ca.
Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA. Electronic address: David_A_Bennett@rush.edu.
Cuello AC; Department of Neurology and Neurosurgery, McGill University, Montreal, Canada; Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada; Department of Anatomy and Cell Biology, McGill University, Montreal, Canada. Electronic address: claudio.cuello@mcgill.ca.

Neurobiol Dis ; 148: 105150, 2021 01.

Article em En | MEDLINE | ID: mdl-33130223

Assuntos

Doença de Alzheimer/metabolismo; Córtex Cerebral/metabolismo; Metaloproteinase 3 da Matriz/genética; Fator de Crescimento Neural/metabolismo; Doença de Alzheimer/patologia; Animais; Encéfalo/metabolismo; Encéfalo/patologia; Córtex Cerebral/patologia; Disfunção Cognitiva/metabolismo; Disfunção Cognitiva/patologia; Feminino; Masculino; Metaloproteinase 3 da Matriz/metabolismo; Proteólise; RNA Mensageiro/metabolismo; Ratos; Ratos Transgênicos; Fatores Sexuais

Palavras-chave

Alzheimer's disease; Basal forebrain cholinergic neurons; Matrix metalloproteinase-3; NGF metabolic pathway; Nerve growth factor; proNGF

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Córtex Cerebral / Metaloproteinase 3 da Matriz / Fator de Crescimento Neural / Doença de Alzheimer Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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