LRRK2 Inhibition Ameliorates Dexamethasone-Induced Glucose Intolerance via Prevents Impairment in GLUT4 Membrane Translocation in Adipocytes.

Imai, Motoki; Kawakami, Fumitaka; Kubo, Makoto; Kanzaki, Makoto; Maruyama, Hiroko; Kawashima, Rei; Maekawa, Tatsunori; Kurosaki, Yoshifumi; Kojima, Fumiaki; Ichikawa, Takafumi

Imai, Motoki; Kawakami, Fumitaka; Kubo, Makoto; Kanzaki, Makoto; Maruyama, Hiroko; Kawashima, Rei; Maekawa, Tatsunori; Kurosaki, Yoshifumi; Kojima, Fumiaki; Ichikawa, Takafumi.

Afiliação

Imai M; Department of Regulation Biochemistry, Graduate School of Medical Sciences, Kitasato University.
Kawakami F; Department of Regulation Biochemistry, Graduate School of Medical Sciences, Kitasato University.
Kubo M; Research Facility of Regenerative Medicine and Cell Design, Kitasato University School of Allied Health Science.
Kanzaki M; Research Facility of Regenerative Medicine and Cell Design, Kitasato University School of Allied Health Science.
Maruyama H; Division of Clinical Immunology, Graduate School of Medical Sciences, Kitasato University.
Kawashima R; Department of Biomedical Engineering, Graduate School of Biomedical Engineering, Tohoku University.
Maekawa T; Research Facility of Regenerative Medicine and Cell Design, Kitasato University School of Allied Health Science.
Kurosaki Y; Department of Cytopathology, Graduate School of Medical Sciences, Kitasato University.
Kojima F; Department of Regulation Biochemistry, Graduate School of Medical Sciences, Kitasato University.
Ichikawa T; Research Facility of Regenerative Medicine and Cell Design, Kitasato University School of Allied Health Science.

Biol Pharm Bull ; 43(11): 1660-1668, 2020.

Article em En | MEDLINE | ID: mdl-33132310

Assuntos

Tecido Adiposo/metabolismo; Dexametasona/efeitos adversos; Intolerância à Glucose/patologia; Transportador de Glucose Tipo 4/metabolismo; Serina-Treonina Proteína Quinase-2 com Repetições Ricas em Leucina/metabolismo; Células 3T3-L1; Adipócitos/citologia; Adipócitos/efeitos dos fármacos; Adipócitos/metabolismo; Tecido Adiposo/citologia; Tecido Adiposo/efeitos dos fármacos; Animais; Membrana Celular/efeitos dos fármacos; Membrana Celular/metabolismo; Modelos Animais de Doenças; Glucose/metabolismo; Intolerância à Glucose/induzido quimicamente; Humanos; Serina-Treonina Proteína Quinase-2 com Repetições Ricas em Leucina/genética; Masculino; Camundongos; Camundongos Knockout; Fosforilação/efeitos dos fármacos

Palavras-chave

adipocyte; dexamethasone; glucose intolerance; glucose transporter 4 (GLUT4); leucine-rich repeat kinase 2 (LRRK2)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dexametasona / Tecido Adiposo / Intolerância à Glucose / Transportador de Glucose Tipo 4 / Serina-Treonina Proteína Quinase-2 com Repetições Ricas em Leucina Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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