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Decreased Expression of Sirt1 Contributes to Ocular Behçet's Disease Progression via Th17 and Th22 Response.
Xie, Manyun; Yang, Yan.
Afiliação
  • Xie M; Department of Ophthalmology, The Second Xiangya Hospital of Central South University, Changsha, China.
  • Yang Y; Hunan Clinical Research Center of Ophthalmic Disease, Changsha, China.
Ophthalmic Res ; 64(4): 554-560, 2021.
Article em En | MEDLINE | ID: mdl-33142293
BACKGROUND: Previous studies have indicated that Sirtuin 1 (Sirt1) plays an important role in suppressing inflammatory responses in many diseases. However, the Sirt1 levels and role of Sirt1 in ocular Behçet's disease (OBD) have not been fully elucidated. OBJECTIVE: The objective of this study was to investigate the role of Sirt1 in the pathogenesis of OBD. METHODS: Sirt1 and cytokine levels were measured using ELISA. Cell viability was determined using the Cell Counting Kit-8. The frequencies of Th17 and Th22 cells were detected using flow cytometry. RESULTS: We found decreased expression of Sirt1 in CD4+ T cells obtained from patients with active OBD. SRT1720, an agonist of Sirt1, significantly upregulated Sirt1 expression in CD4+ T cells from patients with active OBD. Sirt1 activation by SRT1720 significantly suppressed the production of interleukin (IL)-17 and IL-22 by CD4+ T cells and inhibited the expansion of Th17 and Th22 cells. CONCLUSION: Our results suggest that decreased Sirt1 expression might be involved in the pathogenesis of OBD and that activation of Sirt1 might be considered a potential target for OBD.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Síndrome de Behçet / Sirtuína 1 Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Síndrome de Behçet / Sirtuína 1 Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article