Synthesis of substituted anilines via a gold-catalyzed three-component reaction.
Org Biomol Chem
; 19(4): 765-769, 2021 01 28.
Article
em En
| MEDLINE
| ID: mdl-33156310
ABSTRACT
A three-component reaction for the synthesis of substituted anilines by a gold(i)-catalyzed domino reaction was developed. Cationic gold catalysts selectively and sequentially activated two different alkynes, which were involved in pyrrole synthesis and subsequent Diels-Alder reaction. The sequential formal (3 + 2) annulation/Diels-Alder reaction of three components provided a variety of substituted anilines in a modular fashion. Moreover, utility of the aniline products was demonstrated by derivatization to substituted benzoxazines, which are pharmaceutically important heterocycles.
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MEDLINE
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En
Ano de publicação:
2021
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Article