A multi-kinase inhibitor APG-2449 enhances the antitumor effect of ibrutinib in esophageal squamous cell carcinoma via EGFR/FAK pathway inhibition.

Luo, Qiu-Yun; Zhou, Su-Na; Pan, Wen-Tao; Sun, Jian; Yang, Li-Qiong; Zhang, Lin; Qiu, Miao-Zhen; Yang, Da-Jun

Luo, Qiu-Yun; Zhou, Su-Na; Pan, Wen-Tao; Sun, Jian; Yang, Li-Qiong; Zhang, Lin; Qiu, Miao-Zhen; Yang, Da-Jun.

Afiliação

Luo QY; Department of Experimental Research, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, PR China.
Zhou SN; Department of Experimental Research, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, PR China.
Pan WT; Department of Experimental Research, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, PR China.
Sun J; Department of Clinical Research, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, 651 Dongfeng Road East, Guangzhou, PR China.
Yang LQ; Department of Experimental Research, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, PR China.
Zhang L; Department of Clinical Laboratory, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, 651 Dongfeng Road East, Guangzhou, PR China.
Qiu MZ; Department of Medical Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, 651 Dongfeng Road East, Guangzhou 510060, PR China. Electronic address: qiumzh@sysucc.org.cn.
Yang DJ; Department of Experimental Research, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, PR China. Electronic address: yangdj@sysucc.org.cn.

Biochem Pharmacol ; 183: 114318, 2021 01.

Article em En | MEDLINE | ID: mdl-33159967

Assuntos

Adenina/análogos & derivados; Antineoplásicos/administração & dosagem; Neoplasias Esofágicas/metabolismo; Carcinoma de Células Escamosas do Esôfago/metabolismo; Quinase 1 de Adesão Focal/metabolismo; Piperidinas/administração & dosagem; Inibidores de Proteínas Quinases/administração & dosagem; Adenina/administração & dosagem; Adenina/química; Animais; Antineoplásicos/química; Linhagem Celular Tumoral; Relação Dose-Resposta a Droga; Sinergismo Farmacológico; Receptores ErbB/antagonistas & inibidores; Receptores ErbB/metabolismo; Neoplasias Esofágicas/tratamento farmacológico; Carcinoma de Células Escamosas do Esôfago/tratamento farmacológico; Feminino; Quinase 1 de Adesão Focal/antagonistas & inibidores; Humanos; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Nus; Piperidinas/química; Inibidores de Proteínas Quinases/química; Transdução de Sinais/efeitos dos fármacos; Transdução de Sinais/fisiologia; Ensaios Antitumorais Modelo de Xenoenxerto/métodos

Palavras-chave

Combination therapy; EGFR; ESCC; FAK; Ibrutinib

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperidinas / Neoplasias Esofágicas / Adenina / Inibidores de Proteínas Quinases / Quinase 1 de Adesão Focal / Carcinoma de Células Escamosas do Esôfago / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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