[Marrowlogy: a key aspect for the deep understanding of clinical hematology].

ABSTRACT

Mammals have developed bone marrow (BM) inside the bone tissue because of evolution. Now, it appears that bone tissue displays functional communication with the hematopoietic system. Osteoblast lineage cells serve as a part of the microenvironment for immature hematopoietic cells, whereas mature hematopoietic cells play important roles in regulating osteoblast activity. The nervous system maintains the balance between the hematopoietic and skeletal systems. An understanding of the multiple-organ network that exists between the BM and other systems is useful to elucidate phenomena in clinical hematology and even in other fields, an area which I propose to call "marrowlogy."