Your browser doesn't support javascript.
loading
Human neuropeptide substance P self-assembles into semi-flexible nanotubes that can be manipulated for nanotechnology.
Dharmadana, Durga; Adamcik, Jozef; Ryan, Timothy M; Appiah Danso, Samuel; Chong, Christopher J H; Conn, Charlotte E; Reynolds, Nicholas P; Mezzenga, Raffaele; Valéry, Céline.
Afiliação
  • Dharmadana D; School of Health and Biomedical Sciences, Translational Immunology and Nanotechnology (TIN) Program, RMIT University, Bundoora VIC3083, Australia. celine.valery@rmit.edu.au.
Nanoscale ; 12(44): 22680-22687, 2020 Nov 19.
Article em En | MEDLINE | ID: mdl-33165459
Substance P neuropeptide is here reported to self-assemble into well-defined semi-flexible nanotubes. Using a blend of synchrotron small angle X-ray scattering, atomic force microscopy and other biophysical techniques, the natural peptide is shown to self-assemble into monodisperse 6 nm wide nanotubes, which can closely associate into nano-arrays with nematic properties. Using simple protocols, the nanotubes could be precipitated or mineralised while conserving their dimensions and core-shell morphology. Our discovery expands the small number of available monodisperse peptide nanotube systems for nanotechnology, beyond direct relevance to biologically functional peptide nanostructures since the substance P nanotubes are fundamentally different from typical amyloid fibrils.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Nanotubos / Nanoestruturas Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Nanotubos / Nanoestruturas Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article