Skin intrinsic fluorescence scores are a predictor of all-cause mortality risk in type 1 diabetes: The Epidemiology of Diabetes Complications study.
J Diabetes Complications
; 35(2): 107770, 2021 02.
Article
em En
| MEDLINE
| ID: mdl-33168396
ABSTRACT
AIMS:
We assessed the association of skin intrinsic fluorescence (SIF) scores, as a measure of advanced glycation end-products (AGE), with all-cause mortality in type 1 diabetes (T1D).METHODS:
This is an observational retrospective study of a convenience sample from the Epidemiology of Diabetes Complications (EDC) study. AGEs were measured with a SIF score between 2007 and 2014; vital status was assessed in 2020.RESULTS:
Among 245 participants, mean age was 48.6⯱â¯7.4â¯years, median diabetes duration was 39.5â¯years (IQR 34.2, 44.9), and 53.5% were female. Compared to survivors, the deceased (nâ¯=â¯20) were older, with higher SIF scores, longer diabetes duration, lower body mass index (BMI), and an adverse risk factor profile (all p≤0.05). Univariate Cox regression showed a marginal association between SIF score and mortality (HR 1.1, 95% CI 0.9-1.2, pâ¯=â¯0.06), which persisted after adjustment for multiple daily insulin shots/pump (MDI) use (HR 1.1, 95% CI 1.0-1.2, pâ¯=â¯0.04). This association was attenuated after adjustment for T1D duration, A1c months, or estimated glomerular filtration rate (eGFR).CONCLUSIONS:
In individuals with long duration T1D, SIF scores adjusted for MDI predicted all-cause mortality, although this association was attenuated after adjustments. Given the nature of sampling and small number of events, our findings require replication.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Pele
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Mortalidade
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Produtos Finais de Glicação Avançada
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Complicações do Diabetes
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Diabetes Mellitus Tipo 1
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Fluorescência
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
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Screening_studies
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article