Your browser doesn't support javascript.
loading
Oncogenic allelic interaction in Xiphophorus highlights hybrid incompatibility.
Lu, Yuan; Sandoval, Angel; Voss, Sarah; Lai, Zhao; Kneitz, Susanne; Boswell, Will; Boswell, Mikki; Savage, Markita; Walter, Christi; Warren, Wes; Schartl, Manfred; Walter, Ronald.
Afiliação
  • Lu Y; The Xiphophorus Genetic Stock Center, Texas State University, San Marcos, TX 78666; y_l54@txstate.edu rw12@txstate.edu.
  • Sandoval A; The Xiphophorus Genetic Stock Center, Texas State University, San Marcos, TX 78666.
  • Voss S; The Xiphophorus Genetic Stock Center, Texas State University, San Marcos, TX 78666.
  • Lai Z; Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229.
  • Kneitz S; Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229.
  • Boswell W; Physiological Chemistry, Biozentrum, University of Würzburg, 97070 Würzburg, Germany.
  • Boswell M; The Xiphophorus Genetic Stock Center, Texas State University, San Marcos, TX 78666.
  • Savage M; The Xiphophorus Genetic Stock Center, Texas State University, San Marcos, TX 78666.
  • Walter C; The Xiphophorus Genetic Stock Center, Texas State University, San Marcos, TX 78666.
  • Warren W; Department of Cellular & Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229.
  • Schartl M; Bond Life Science Center, University of Missouri, Columbia, MO 65211.
  • Walter R; The Xiphophorus Genetic Stock Center, Texas State University, San Marcos, TX 78666.
Proc Natl Acad Sci U S A ; 117(47): 29786-29794, 2020 11 24.
Article em En | MEDLINE | ID: mdl-33168740
Mixing genomes of different species by hybridization can disrupt species-specific genetic interactions that were adapted and fixed within each species population. Such disruption can predispose the hybrids to abnormalities and disease that decrease the overall fitness of the hybrids and is therefore named as hybrid incompatibility. Interspecies hybridization between southern platyfish and green swordtails leads to lethal melanocyte tumorigenesis. This occurs in hybrids with tumor incidence following progeny ratio that is consistent with two-locus interaction, suggesting melanoma development is a result of negative epistasis. Such observations make Xiphophorus one of the only two vertebrate hybrid incompatibility examples in which interacting genes have been identified. One of the two interacting loci has been characterized as a mutant epidermal growth factor receptor. However, the other locus has not been identified despite over five decades of active research. Here we report the localization of the melanoma regulatory locus to a single gene, rab3d, which shows all expected features of the long-sought oncogene interacting locus. Our findings provide insights into the role of egfr regulation in regard to cancer etiology. Finally, they provide a molecular explainable example of hybrid incompatibility.
Assuntos
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ciprinodontiformes / Doenças dos Peixes / Hibridização Genética / Melanoma / Modelos Genéticos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ciprinodontiformes / Doenças dos Peixes / Hibridização Genética / Melanoma / Modelos Genéticos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article