Elevated COVID-19 outcomes among persons living with diagnosed HIV infection in New York State: Results from a population-level match of HIV, COVID-19, and hospitalization databases.
medRxiv
; 2020 Nov 06.
Article
em En
| MEDLINE
| ID: mdl-33173901
ABSTRACT
BACKGROUND:
New York State (NYS) has been an epicenter for both COVID-19 and HIV/AIDS epidemics. Persons Living with diagnosed HIV (PLWDH) may be more prone to COVID-19 infection and severe outcomes, yet few population-based studies have assessed the extent to which PLWDH are diagnosed, hospitalized, and have died with COVID-19, relative to non-PLWDH.METHODS:
NYS HIV surveillance, COVID-19 laboratory confirmed diagnoses, and hospitalization databases were matched. COVID-19 diagnoses, hospitalization, and in-hospital death rates comparing PLWDH to non-PLWDH were computed, with unadjusted rate ratios (RR) and indirect standardized RR (sRR), adjusting for sex, age, and region. Adjusted RR (aRR) for outcomes among PLWDH were assessed by age/CD4-defined HIV disease stage, and viral load suppression, using Poisson regression models.RESULTS:
From March 1-June 7, 2020, PLWDH were more frequently diagnosed with COVID-19 than non-PLWDH in unadjusted (RR [95% confidence interval (CI)] 1.43[1.38-1.48), 2,988 PLWDH], but not in adjusted comparisons (sRR [95% CI] 0.94[0.91-0.97]). Per-population COVID-19 hospitalization was higher among PLWDH (RR [95% CI] 2.61[2.45-2.79], sRR [95% CI] 1.38[1.29-1.47], 896 PLWDH), as was in-hospital death (RR [95% CI] 2.55[2.22-2.93], sRR [95%CI] 1.23 [1.07-1.40], 207 PLWDH), albeit not among those hospitalized (sRR [95% CI] 0.96[0.83-1.09]). Among PLWDH, hospitalization risk increased with disease progression from HIV Stage 1 to Stage 2 (aRR [95% CI]1.27[1.09-1.47]) and Stage 3 (aRR [95% CI] 1.54[1.24-1.91]), and for those virally unsuppressed (aRR [95% CI] 1.54[1.24-1.91]).CONCLUSION:
PLWDH experienced poorer COVID-related outcomes relative to non-PLWDH, with 1-in-522 PLWDH dying with COVID-19, seemingly driven by higher rates of severe disease requiring hospitalization.
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Base de dados:
MEDLINE
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article