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Kinetics of Torque Teno virus DNA in stools may predict occurrence of acute intestinal graft versus host disease early after allogeneic hematopoietic stem cell transplantation.
Bueno, Felipe; Albert, Eliseo; Piñana, José Luis; Pérez, Ariadna; Úbeda, Carlos; Gómez, María Dolores; Hernández-Boluda, Juan Carlos; Gonzalez-Barberá, Eva María; Montoro, Juan; Giménez, Estela; Guerreiro, Manuel; Balaguer-Roselló, Aitana; Hernani, Rafael; Sanz, Jaime; Solano, Carlos; Navarro, David.
Afiliação
  • Bueno F; Microbiology Service, Hospital Clínico Universitario, Institute for Research INCLIVA, Valencia, Spain.
  • Albert E; Microbiology Service, Hospital Clínico Universitario, Institute for Research INCLIVA, Valencia, Spain.
  • Piñana JL; Hematology Department, Hospital Universitari i Politècnic La Fe, Valencia, Spain.
  • Pérez A; Hematology Service, Hospital Clínico Universitario, Institute for Research INCLIVA Valencia, Spain.
  • Úbeda C; Centro Superior de Investigacion en Salud Publica - FISABIO, Valencia, Spain.
  • Gómez MD; Microbiology Service, Hospital Universitari i Politècnic La Fe, Valencia, Spain.
  • Hernández-Boluda JC; Hematology Service, Hospital Clínico Universitario, Institute for Research INCLIVA Valencia, Spain.
  • Gonzalez-Barberá EM; Microbiology Service, Hospital Universitari i Politècnic La Fe, Valencia, Spain.
  • Montoro J; Hematology Department, Hospital Universitari i Politècnic La Fe, Valencia, Spain.
  • Giménez E; Microbiology Service, Hospital Clínico Universitario, Institute for Research INCLIVA, Valencia, Spain.
  • Guerreiro M; Hematology Department, Hospital Universitari i Politècnic La Fe, Valencia, Spain.
  • Balaguer-Roselló A; Hematology Department, Hospital Universitari i Politècnic La Fe, Valencia, Spain.
  • Hernani R; Hematology Service, Hospital Clínico Universitario, Institute for Research INCLIVA Valencia, Spain.
  • Sanz J; Hematology Department, Hospital Universitari i Politècnic La Fe, Valencia, Spain.
  • Solano C; Hematology Service, Hospital Clínico Universitario, Institute for Research INCLIVA Valencia, Spain.
  • Navarro D; Department of Medicine, School of Medicine, University of Valencia, Valencia, Spain.
Transpl Infect Dis ; 23(3): e13507, 2021 Jun.
Article em En | MEDLINE | ID: mdl-33176050
ABSTRACT
Torque Teno virus (TTV) DNA load in blood may act as a marker of immune competence after allogeneic hematopoietic stem cell transplant recipients (allo-HSCT). Conflicting data have been reported as to the value of this biomarker for anticipating acute Graft versus host disease (aGvHD) occurrence. Here, we hypothesized that quantitation of TTV DNA load in stool specimens early after allo-HSCT could be used to identify patients at high risk of acute intestinal graft versus host disease (aIGvHD). In this prospective two-center study, we recruited a total of 83 nonconsecutive adult patients undergoing allo-HSCT. The study period comprised the first 120 days after allo-HSCT. TTV DNA was quantitated in paired stool samples collected at a median of 2 days prior to cell infusion and at a median of 14 days after allo-HSCT by real-time PCR. Thirty-seven patients developed aGVHD, of whom 25 had aIGVHD (diagnosed at a median of 42 days after allo-HSCT). Median TTV DNA load values in posttransplant stools specimens were comparable (P = .34) in patients with or without subsequent aIGvHD; nevertheless, a falling trajectory (decrease in TTV DNA load >0.5 log10 copies/0.1 g) in paired pretransplant and posttransplant specimens was independently associated with the occurrence of aIGvHD (OR, 5.2; 95% CI, 1.3-21.3; P = .02). Notably, displaying a rising trajectory had a negative predictive value of 87.5% for aIGvHD. In summary, in this hypothesis-generating study, we suggest that the decrease in TTV DNA load from baseline in stool specimens may identify patients at risk of aIGVHD.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transplante de Células-Tronco Hematopoéticas / Torque teno virus / Infecções por Vírus de DNA / Doença Enxerto-Hospedeiro Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transplante de Células-Tronco Hematopoéticas / Torque teno virus / Infecções por Vírus de DNA / Doença Enxerto-Hospedeiro Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article