Dual self-regulated delivery of insulin and glucagon by a hybrid patch.
Proc Natl Acad Sci U S A
; 117(47): 29512-29517, 2020 11 24.
Article
em En
| MEDLINE
| ID: mdl-33177238
ABSTRACT
Reduced ß-cell function and insulin deficiency are hallmarks of diabetes mellitus, which is often accompanied by the malfunction of glucagon-secreting α-cells. While insulin therapy has been developed to treat insulin deficiency, the on-demand supplementation of glucagon for acute hypoglycemia treatment remains inadequate. Here, we describe a transdermal patch that mimics the inherent counterregulatory effects of ß-cells and α-cells for blood glucose management by dynamically releasing insulin or glucagon. The two modules share a copolymerized matrix but comprise different ratios of the key monomers to be "dually responsive" to both hyper- and hypoglycemic conditions. In a type 1 diabetic mouse model, the hybrid patch effectively controls hyperglycemia while minimizing the occurrence of hypoglycemia in the setting of insulin therapy with simulated delayed meal or insulin overdose.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Glucagon
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Sistemas de Liberação de Medicamentos
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Diabetes Mellitus Experimental
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Diabetes Mellitus Tipo 1
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Hipoglicemiantes
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Insulina
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Animals
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Humans
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Male
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article