MPL Adjuvant Contains Competitive Antagonists of Human TLR4.

Wang, Yi-Qi; Bazin-Lee, Hélène; Evans, Jay T; Casella, Carolyn R; Mitchell, Thomas C

Wang, Yi-Qi; Bazin-Lee, Hélène; Evans, Jay T; Casella, Carolyn R; Mitchell, Thomas C.

Afiliação

Wang YQ; School of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou, China.
Bazin-Lee H; Center for Translational Medicine, University of Montana, Missoula, MT, United States.
Evans JT; Center for Translational Medicine, University of Montana, Missoula, MT, United States.
Casella CR; Department of Microbiology and Immunology, School of Medicine, University of Louisville, Louisville, KY, United States.
Mitchell TC; Department of Microbiology and Immunology, School of Medicine, University of Louisville, Louisville, KY, United States.

Front Immunol ; 11: 577823, 2020.

Article em En | MEDLINE | ID: mdl-33178204

Assuntos

Adjuvantes Imunológicos/farmacologia; Lipídeo A/análogos & derivados; Macrófagos/efeitos dos fármacos; Receptor 4 Toll-Like/antagonistas & inibidores; Animais; Relação Dose-Resposta a Droga; Agonismo Parcial de Drogas; Humanos; Lipídeo A/farmacologia; Macrófagos/metabolismo; Camundongos; Camundongos Endogâmicos BALB C; Células RAW 264.7; Especificidade da Espécie; Células THP-1; Receptor 4 Toll-Like/genética; Receptor 4 Toll-Like/metabolismo

Palavras-chave

Toll-like receptor 4 (TLR4); monophosphoryl lipid A (MPL); partial agonist; reactogenicity; safety; vaccine adjuvant

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Adjuvantes Imunológicos / Receptor 4 Toll-Like / Lipídeo A / Macrófagos Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google