Why is oocyte aneuploidy increased with maternal aging?
J Genet Genomics
; 47(11): 659-671, 2020 11 20.
Article
em En
| MEDLINE
| ID: mdl-33184002
ABSTRACT
One of the main causes of pregnancy failure and fetus abortion is oocyte aneuploidy, which is increased with maternal aging. Numerous possible causes of oocyte aneuploidy in aged women have been proposed, including cross-over formation defect, cohesin loss, spindle deformation, spindle assembly checkpoint malfunction, microtubule-kinetochore attachment failure, kinetochore mis-orientation, mitochondria dysfunction-induced increases in reactive oxygen species, protein over-acetylation, and DNA damage. However, it still needs to be answered if these aneuploidization factors have inherent relations, and how to prevent chromosome aneuploidy in aged oocytes. Epidemiologically, oocyte aneuploidy has been found to be weakly associated with higher homocysteine concentrations, obesity, ionizing radiation and even seasonality. In this review, we summarize the research progress and present an integrated view of oocyte aneuploidization.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Oócitos
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Idade Materna
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Aneuploidia
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Meiose
Limite:
Aged
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Animals
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Female
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Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article