Membrane proteomic profiling of the heart: past, present, and future.
Am J Physiol Heart Circ Physiol
; 320(1): H417-H423, 2021 01 01.
Article
em En
| MEDLINE
| ID: mdl-33185114
ABSTRACT
Cardiovascular diseases remain the most rapidly rising contributing factor of all-cause mortality and the leading cause of inpatient hospitalization worldwide, with costs exceeding $30 billion annually in North America. Cell surface and membrane-associated proteins play an important role in cardiomyocyte biology and are involved in the pathogenesis of many human heart diseases. In cardiomyocytes, membrane proteins serve as critical signaling receptors, Ca2+ cycling regulators, and electrical propagation regulators, all functioning in concert to maintain spontaneous and synchronous contractions of cardiomyocytes. Membrane proteins are excellent pharmaceutical targets due to their uniquely exposed position within the cell. Perturbations in cardiac membrane protein localization and function have been implicated in the progression and pathogenesis of many heart diseases. However, previous attempts at profiling the cardiac membrane proteome have yielded limited results due to poor technological developments for isolating hydrophobic, low-abundance membrane proteins. Comprehensive mapping and characterization of the cardiac membrane proteome thereby remains incomplete. This review will focus on recent advances in mapping the cardiac membrane proteome and the role of novel cardiac membrane proteins in the healthy and the diseased heart.
Palavras-chave
Texto completo:
1
Eixos temáticos:
Inovacao_tecnologica
Base de dados:
MEDLINE
Assunto principal:
Membrana Celular
/
Miócitos Cardíacos
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Proteômica
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Cardiopatias
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Proteínas de Membrana
Tipo de estudo:
Prognostic_studies
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Sysrev_observational_studies
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article