Glycine 236 in the Lower Hinge Region of Human IgG1 Differentiates FcÎ³R from Complement Effector Function.

Brinkhaus, Maximilian; Douwes, Ruben G J; Bentlage, Arthur E H; Temming, A Robin; de Taeye, Steven W; Tammes Buirs, Matthias; Gerritsen, Jacoline; Mok, Juk Yee; Brasser, Giso; Ligthart, Peter C; van Esch, Wim J E; Verheesen, Peter; de Haard, Hans; Rispens, Theo; Vidarsson, Gestur

Brinkhaus, Maximilian; Douwes, Ruben G J; Bentlage, Arthur E H; Temming, A Robin; de Taeye, Steven W; Tammes Buirs, Matthias; Gerritsen, Jacoline; Mok, Juk Yee; Brasser, Giso; Ligthart, Peter C; van Esch, Wim J E; Verheesen, Peter; de Haard, Hans; Rispens, Theo; Vidarsson, Gestur.

Afiliação

Brinkhaus M; Department of Experimental Immunohematology, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, 1066 CX, Amsterdam, the Netherlands.
Douwes RGJ; Department of Experimental Immunohematology, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, 1066 CX, Amsterdam, the Netherlands.
Bentlage AEH; Department of Experimental Immunohematology, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, 1066 CX, Amsterdam, the Netherlands.
Temming AR; Department of Experimental Immunohematology, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, 1066 CX, Amsterdam, the Netherlands.
de Taeye SW; Department of Experimental Immunohematology, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, 1066 CX, Amsterdam, the Netherlands.
Tammes Buirs M; Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, 1066 CX Amsterdam, the Netherlands.
Gerritsen J; Department of Experimental Immunohematology, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, 1066 CX, Amsterdam, the Netherlands.
Mok JY; Department of Experimental Immunohematology, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, 1066 CX, Amsterdam, the Netherlands.
Brasser G; Sanquin Reagents, 1066 CX Amsterdam, the Netherlands.
Ligthart PC; Sanquin Reagents, 1066 CX Amsterdam, the Netherlands.
van Esch WJE; Sanquin Diagnostic Services, Department of Immunohematology Diagnostics, 1066 CX Amsterdam, the Netherlands; and.
Verheesen P; Sanquin Reagents, 1066 CX Amsterdam, the Netherlands.
de Haard H; argenx, 9052 Zwijnaarde, Belgium.
Rispens T; argenx, 9052 Zwijnaarde, Belgium.
Vidarsson G; Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, 1066 CX Amsterdam, the Netherlands.

J Immunol ; 205(12): 3456-3467, 2020 12 15.

Article em En | MEDLINE | ID: mdl-33188070

Assuntos

Sequência de Aminoácidos; Ativação do Complemento; Complemento C1q; Imunoglobulina G; Receptores de IgG; Deleção de Sequência; Ressonância de Plasmônio de Superfície; Complemento C1q/química; Complemento C1q/genética; Complemento C1q/imunologia; Glicina/química; Glicina/genética; Glicina/imunologia; Células HEK293; Humanos; Imunoglobulina G/química; Imunoglobulina G/genética; Imunoglobulina G/imunologia; Receptores de IgG/química; Receptores de IgG/genética; Receptores de IgG/imunologia

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Imunoglobulina G / Complemento C1q / Sequência de Aminoácidos / Deleção de Sequência / Receptores de IgG / Ativação do Complemento / Ressonância de Plasmônio de Superfície Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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