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Genome-wide association analysis of type 2 diabetes in the EPIC-InterAct study.
Cai, Lina; Wheeler, Eleanor; Kerrison, Nicola D; Luan, Jian'an; Deloukas, Panos; Franks, Paul W; Amiano, Pilar; Ardanaz, Eva; Bonet, Catalina; Fagherazzi, Guy; Groop, Leif C; Kaaks, Rudolf; Huerta, José María; Masala, Giovanna; Nilsson, Peter M; Overvad, Kim; Pala, Valeria; Panico, Salvatore; Rodriguez-Barranco, Miguel; Rolandsson, Olov; Sacerdote, Carlotta; Schulze, Matthias B; Spijkerman, Annemieke M W; Tjonneland, Anne; Tumino, Rosario; van der Schouw, Yvonne T; Sharp, Stephen J; Forouhi, Nita G; Riboli, Elio; McCarthy, Mark I; Barroso, Inês; Langenberg, Claudia; Wareham, Nicholas J.
Afiliação
  • Cai L; MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.
  • Wheeler E; MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.
  • Kerrison ND; MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.
  • Luan J; MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.
  • Deloukas P; Clinical Pharmacology Centre, Queen Mary University of London, London, United Kingdom.
  • Franks PW; Department of Clinical Sciences, Clinical Research Center, Skåne University Hospital, Lund University, 20502, Malmö, Sweden.
  • Amiano P; Department of Public Health and Clinical Medicine, Umeå University, 90187, Umeå, Sweden.
  • Ardanaz E; Ministry of Health of the Basque Government, Public Health Division of Gipuzkoa, Biodonostia Health Research Institute, Donostia-San Sebastian, Spain.
  • Bonet C; Navarra Public Health Institute, Pamplona, Spain.
  • Fagherazzi G; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain.
  • Groop LC; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
  • Kaaks R; Unit of Nutrition and Cancer, Catalan Institute of Oncology - ICO, Nutrition and Cancer Group, Bellvitge Biomedical Research Institute - IDIBELL, L'Hospitalet de Llobregat, Barcelona, 08908, Spain.
  • Huerta JM; Digital Epidemiology and e-Health Research Hub, Department of Population Health, Luxembourg Institute of Health, 1A-B, rue Thomas Edison, L-1445, Strassen, Luxembourg.
  • Masala G; Center of Epidemiology and Population Health UMR 1018, Inserm, Paris South - Paris Saclay University, Gustave Roussy Institute, Villejuif, France.
  • Nilsson PM; Department of Clinical Sciences, Clinical Research Center, Skåne University Hospital, Lund University, 20502, Malmö, Sweden.
  • Overvad K; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120, Heidelberg, Germany.
  • Pala V; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
  • Panico S; Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain.
  • Rodriguez-Barranco M; Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network - ISPRO, Florence, Italy.
  • Rolandsson O; Department of Clinical Sciences, Clinical Research Center, Skåne University Hospital, Lund University, 20502, Malmö, Sweden.
  • Sacerdote C; Department of Public Health, Aarhus University, Bartholins Allé 2, DK-8000, Aarhus C, Denmark.
  • Schulze MB; Department of Cardiology, Aalborg University Hospital, Sdr. Skovvej 15, DK-9000, Aalborg, Denmark.
  • Spijkerman AMW; Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
  • Tjonneland A; Dipartimento di Medicina Clinica e Chirurgia, Federico II University, via Pansini 5, 80131, Naples, Italy.
  • Tumino R; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
  • van der Schouw YT; Escuela Andaluza de Salud Pública (EASP), Granada, Spain.
  • Sharp SJ; Instituto de Investigación Biosanitaria ibs.Granada, Granada, Spain.
  • Forouhi NG; Department of Public Health and Clinical Medicine, Umeå University, 90187, Umeå, Sweden.
  • Riboli E; Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital and Center for Cancer Prevention (CPO), Turin, Italy.
  • McCarthy MI; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
  • Barroso I; German Center for Diabetes Research (DZD), Neuherberg, Germany.
  • Langenberg C; Institute of Nutrition Science, University of Potsdam, Nuthetal, Germany.
  • Wareham NJ; National Institute for Public Health and the Environment (RIVM), PO Box 1, 3720 BA, Bilthoven, The Netherlands.
Sci Data ; 7(1): 393, 2020 11 13.
Article em En | MEDLINE | ID: mdl-33188205
ABSTRACT
Type 2 diabetes (T2D) is a global public health challenge. Whilst the advent of genome-wide association studies has identified >400 genetic variants associated with T2D, our understanding of its biological mechanisms and translational insights is still limited. The EPIC-InterAct project, centred in 8 countries in the European Prospective Investigations into Cancer and Nutrition study, is one of the largest prospective studies of T2D. Established as a nested case-cohort study to investigate the interplay between genetic and lifestyle behavioural factors on the risk of T2D, a total of 12,403 individuals were identified as incident T2D cases, and a representative sub-cohort of 16,154 individuals was selected from a larger cohort of 340,234 participants with a follow-up time of 3.99 million person-years. We describe the results from a genome-wide association analysis between more than 8.9 million SNPs and T2D risk among 22,326 individuals (9,978 cases and 12,348 non-cases) from the EPIC-InterAct study. The summary statistics to be shared provide a valuable resource to facilitate further investigations into the genetics of T2D.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 2 / Estudo de Associação Genômica Ampla / Estilo de Vida Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans País como assunto: Europa Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 2 / Estudo de Associação Genômica Ampla / Estilo de Vida Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans País como assunto: Europa Idioma: En Ano de publicação: 2020 Tipo de documento: Article