Screening for potential familial hypercholesterolaemia in general practice: an observational study on prevalence and management.
BJGP Open
; 5(2)2021 Apr.
Article
em En
| MEDLINE
| ID: mdl-33199307
ABSTRACT
BACKGROUND:
Familial hypercholesterolaemia (FH) is a common genetic disorder causing premature cardiovascular disease (CVD). The estimated prevalence of probable or definite FH is 1200-250 individuals, according to the Dutch Lipid Clinic Network (DLCN) criteria for FH. In Denmark approximately 12% of cases are identified.AIM:
To provide knowledge of the prevalence and management of FH in general practice. DESIGN &SETTING:
A collaboration between six general practice clinics and the department of cardiology at Bispebjerg hospital in Denmark.METHOD:
A total of 9652 patient records were screened for hypercholesterolaemia. All patients with a low-density lipoprotein cholesterol (LDL-C) ≥5.0 mmol/l were included in the study population and their records were investigated in order to perform a diagnostic score according to the DLCN criteria.RESULTS:
It was found that 2382 individuals had a lipid measurement available, and 236 of those had an LDL-C ≥5.0 mmol/l. In total, 34 individuals were found to have probable or definite FH (DLCN score ≥5). Only three individuals had been diagnosed and treated with lipid-lowering therapy. Of 236 individuals with high LDL-C, only 25 individuals met their treatment target. By excluding patients with signs of secondary hypercholesterolaemia, a subgroup of 115 individuals with potential primary hypercholesterolaemia was established. Among those, 21 individuals were found to have probable or definite FH (1114 individuals).CONCLUSION:
The study shows that there is a massive lack of recognition of FH in general practice. Despite a measured high LDL-C, the diagnosis is rarely made and only a few patients are treated accordingly. Of the patients undergoing treatment, only a few reached their treatment target.
Texto completo:
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Base de dados:
MEDLINE
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
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Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
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Screening_studies
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article