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The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase.
Lilic, Mirjana; Chen, James; Boyaci, Hande; Braffman, Nathaniel; Hubin, Elizabeth A; Herrmann, Jennifer; Müller, Rolf; Mooney, Rachel; Landick, Robert; Darst, Seth A; Campbell, Elizabeth A.
Afiliação
  • Lilic M; Laboratory of Molecular Biophysics, The Rockefeller University, New York, NY 10065.
  • Chen J; Laboratory of Molecular Biophysics, The Rockefeller University, New York, NY 10065.
  • Boyaci H; Laboratory of Molecular Biophysics, The Rockefeller University, New York, NY 10065.
  • Braffman N; Laboratory of Molecular Biophysics, The Rockefeller University, New York, NY 10065.
  • Hubin EA; Laboratory of Molecular Biophysics, The Rockefeller University, New York, NY 10065.
  • Herrmann J; Department Microbial Natural Products, Helmholtz Institute for Pharmaceutical Research Saarland, Helmholtz Centre for Infection Research, Saarland University, 66123 Saarbrücken, Germany.
  • Müller R; Department of Pharmacy, Saarland University, 66123 Saarbrücken, Germany.
  • Mooney R; Partner Site Hannover-Braunschweig, German Center for Infection Research, 38124 Braunschweig, Germany.
  • Landick R; Department Microbial Natural Products, Helmholtz Institute for Pharmaceutical Research Saarland, Helmholtz Centre for Infection Research, Saarland University, 66123 Saarbrücken, Germany.
  • Darst SA; Department of Pharmacy, Saarland University, 66123 Saarbrücken, Germany.
  • Campbell EA; Partner Site Hannover-Braunschweig, German Center for Infection Research, 38124 Braunschweig, Germany.
Proc Natl Acad Sci U S A ; 117(48): 30423-30432, 2020 12 01.
Article em En | MEDLINE | ID: mdl-33199626
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: RNA Polimerases Dirigidas por DNA / Regiões Promotoras Genéticas / Farmacorresistência Bacteriana / Aminoglicosídeos / Antibióticos Antituberculose / Mycobacterium tuberculosis Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: RNA Polimerases Dirigidas por DNA / Regiões Promotoras Genéticas / Farmacorresistência Bacteriana / Aminoglicosídeos / Antibióticos Antituberculose / Mycobacterium tuberculosis Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article