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AMG 757, a Half-Life Extended, DLL3-Targeted Bispecific T-Cell Engager, Shows High Potency and Sensitivity in Preclinical Models of Small-Cell Lung Cancer.
Giffin, Michael J; Cooke, Keegan; Lobenhofer, Edward K; Estrada, Juan; Zhan, Jinghui; Deegen, Petra; Thomas, Melissa; Murawsky, Christopher M; Werner, Jonathan; Liu, Siyuan; Lee, Fei; Homann, Oliver; Friedrich, Matthias; Pearson, Joshua T; Raum, Tobias; Yang, Yajing; Caenepeel, Sean; Stevens, Jennitte; Beltran, Pedro J; Canon, Jude; Coxon, Angela; Bailis, Julie M; Hughes, Paul E.
Afiliação
  • Giffin MJ; Oncology Research, Amgen Research, Thousand Oaks, California.
  • Cooke K; Oncology Research, Amgen Research, Thousand Oaks, California.
  • Lobenhofer EK; Translational Safety & Bioanalytical Sciences, Amgen Research, Thousand Oaks, California.
  • Estrada J; Oncology Research, Amgen Research, Thousand Oaks, California.
  • Zhan J; Oncology Research, Amgen Research, Thousand Oaks, California.
  • Deegen P; Translational Safety & Bioanalytical Sciences, Amgen Research (Munich) GmbH, Munich, Germany.
  • Thomas M; Therapeutic Discovery, Amgen Research, South San Francisco, California.
  • Murawsky CM; Therapeutic Discovery, Amgen Research, Burnaby, British Columbia, Canada.
  • Werner J; Translational Safety & Bioanalytical Sciences, Amgen Research, Thousand Oaks, California.
  • Liu S; Oncology Research, Amgen Research, Thousand Oaks, California.
  • Lee F; Oncology Research, Amgen Research, South San Francisco, California.
  • Homann O; Genome Analysis Unit, Amgen Research, South San Francisco, California.
  • Friedrich M; Translational Safety & Bioanalytical Sciences, Amgen Research (Munich) GmbH, Munich, Germany.
  • Pearson JT; Pharmacokinetics & Drug Metabolism, Amgen Research, South San Francisco, California.
  • Raum T; Therapeutic Discovery, Amgen Research (Munich) GmbH, Munich, Germany.
  • Yang Y; Oncology Research, Amgen Research, Thousand Oaks, California.
  • Caenepeel S; Oncology Research, Amgen Research, Thousand Oaks, California.
  • Stevens J; Therapeutic Discovery, Amgen Research, Thousand Oaks, California.
  • Beltran PJ; Oncology Research, Amgen Research, Thousand Oaks, California.
  • Canon J; Oncology Research, Amgen Research, Thousand Oaks, California.
  • Coxon A; Oncology Research, Amgen Research, Thousand Oaks, California.
  • Bailis JM; Oncology Research, Amgen Research, South San Francisco, California. phughes@amgen.com jbailis@amgen.com.
  • Hughes PE; Oncology Research, Amgen Research, Thousand Oaks, California. phughes@amgen.com jbailis@amgen.com.
Clin Cancer Res ; 27(5): 1526-1537, 2021 03 01.
Article em En | MEDLINE | ID: mdl-33203642
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos T / Regulação Neoplásica da Expressão Gênica / Anticorpos Biespecíficos / Peptídeos e Proteínas de Sinalização Intracelular / Carcinoma de Pequenas Células do Pulmão / Neoplasias Pulmonares / Proteínas de Membrana / Anticorpos Monoclonais Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos T / Regulação Neoplásica da Expressão Gênica / Anticorpos Biespecíficos / Peptídeos e Proteínas de Sinalização Intracelular / Carcinoma de Pequenas Células do Pulmão / Neoplasias Pulmonares / Proteínas de Membrana / Anticorpos Monoclonais Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article